Body mass index, weight change and risk of prostate cancer in the Cancer Prevention Study II Nutrition Cohort
UroToday-Over the past five years, a large body of evidence has accumulated supporting the association between obesity and risk of prostate cancer. Despite these advances in our understanding of carcinogenesis of the prostate, the precise interaction between BMI and the risk of patients remains uncertain. In the January issue of Cancer Epidemiology, Biomarkers, Rodrguez and colleagues report data from the U.S. American Cancer Society Cancer Prevention Study II Nutrition Cohort to evaluate the relationship between obesity and risk of prostate cancer.In addition to its large size, this study is interesting because substratified patients with prostate cancer based on tumor grade and stage.The cohort consisted of 69 991 men who have received the information about size and
weight at baseline (year 1982) and were observed for 20 years long. Patients with high BMI showed a reduced risk of prostate cancer nichtmetastatische low-grade (hazard ratio, 0.84), but showed a greater tendency to high grade prostate cancer with nonmetasteatic (hazard ratio 1.22 are diagnosed, 95% CI 0.96 to 1.55) and an increased risk of dying of metastatic prostate cancer (relative risk 1.54, 95% CI 1.06 to 2.23). Interestingly, men with a recorded weight loss of more than £ 11 (in the first 10 years of the study), a significantly lower risk of developing high-quality non-metastatic prostate cancer (RR 0th58, 95% CI 0.42 to 0.79).These data from a large prospective epidemiological suggest that patients with high BMI are less likely to develop prostate cancer in low
and more likely to develop prostate cancer grade. This dichotomous distribution of risk may partly explain why studies that do not have the patients according to tumor grade substratified had not found an association between obesity and prostate cancer risk. Also, perhaps the most convincing argument in favor of this increased risk has been documented to reduce risk of prostate cancer high-grade modification of diet and weight Pages: [1] 2