Detail of cellular defense against critics of genetic errors discovered by researchers
The researchers are approaching a complete account of how human cells protect themselves constant genetic mistakes that contribute to most diseases, 18 in a study by the April issue of the journal Cell, the plan for the human body is encoded in the genes published. Gene expression is the process by which plans into proteins that make up the structures of the body and send their signals to be translated. When molecular biologists analyze the complete human genome (human genome) began in 2001, was a surprise that humans have only 30,000 genes, if need be, given the complexity, more than 100,000.Like humans, both as a fifth of the genetic material of wheat, for example, or share a quarter of their genes with fish?One answer is that people do more with fewer genes. If genes
strings of deoxyribonucleic acid (DNA), they will be in practice by chains of ribonucleic acid chains (RNA) copies of the modified DNA implemented. Messenger RNA (mRNA) to cellular factories called ribosomes, the instructions for building proteins are transported by reading receive the mRNA template, a process known as translation. It is noteworthy that encode than about 75 percent of human genes for more than one protein through a process of alternative splicing of RNA.Unfortunately, the more complex the splicing process, the greater the chance of error. More than a third of alternatively spliced ​​mRNAs are deficient and must be destroyed before they cause damage. Therefore, the cellular processes that detect and eliminate processing errors are vitally important for
efficient gene expression.In recent years, researchers at the University of Rochester Medical Center have revealed the existence of a natural surveillance system called nonsense-mediated mRNA decay (NMD) that determines which mRNAs are suitable to serve as models protein and provides for the destruction those with defects. The researchers hope to change the process that captures more genetic errors in some cases, leaves
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