Discovered a tumor marker in some benign breast biopsies
There is good news, bad news situation. Some women who have a biopsy, said they have cancer, but not atypical hyperplasia - cells that send as normal and that one day may become cancerous. This is done for a quarter of women who are breast biopsies, but no one knows which individuals are at risk. In his quest to detect those at risk, Mayo Clinic researchers are building a profile of the biopsy to attempt to predict the outcome of cancer, and in the March 11 online edition of the Journal of National Cancer Institute (jnci.Oxford Journals / rss / recent.xml), add the report to find a new variable to this profile.The research team found that women with atypia tissue expressed COX-2 enzymes were more likely to develop breast cancer later, and the more the enzyme expressed, the
greater the risk. In particular, 20 years after a biopsy that was found atypia, 31 percent of women with high levels of COX-2 in their sample had atypia developed breast cancer, compared with 14 percent of those without COX-2. For those with moderate levels of COX-2, 24 percent had developed breast cancer. Based on these findings, COX-2 atypia may be a biomarker of risk of progression to breast cancer, says study lead investigator, Mayo Clinic oncologist Lynn Hartmann, M.D. COX-2 is an important candidate because it manages a number of malignant features and has proven to be important for breast cancer.Each year in the United States, approximately 1 million women have a benign breast biopsy, and some of them receive the disturbing news that atypical hyperplasia, Dr.Hartmann. If further studies validate these results, it appears that a strategy to help patients heal can use an agent to inhibit COX-2 such as celecoxib (en.wikipedia / wiki / celecoxib) or rofecoxib (in . wikipedia / wiki / rofecoxib) to prevent the development of breast cancer. This study raises the possibility of continuing the COX-2 in women selected to reduce the risk of breast cancer, she said.
In terms of age,
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